Streptomycin and Promanide in Experimental Ocular

IT is known that bacteriostatic concentrations of streptomycin can be produced in various tissues of the rabbit's eye after systemic administration (Leopold and Nichols, 1946) ; after application to the conjunctival sac when the cornea is inflamed or abraded, but not otherwise (Id, ibid., and Bellows, Burkholder, and Farmer, 1947); after intravitreous injection; and, rather transiently, after subconjunctival administration (Gardiner, Michaelson, Rees, and Robson, 1948). There appear to be no measurements of the penetration of sulphones into the eye, but Steenken, Wolinsky, and Heise (1946) obtained therapeutic results in guinea pigs with experimentally induced tuberculosis of the eye by subconjunctival or oral administration of sodium p-p'-diaminodiphenylsulphoneN-N'-didextrose sulphonate (" Promin " or " Promanide "). The present paper records some observations on the efficacy of streptomycin and Promanide under various conditions in experimentally produced tuberculosis of the iris and ciliary body of the rabbit's eye.